Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes

Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes.

The development, homeostasis, and function of B lymphocytes involve multiple rounds of B-cell receptor (BCR)-controlled proliferation and prolonged maintenance. We analyzed the role of transcription factor Zfx, a recently identified regulator of hematopoietic stem cell maintenance, in B-cell development and homeostasis. Panhematopoietic or B cell-specific deletion of Zfx in the bone marrow bloc...

Primary Mature B Lymphocytes Transduction and Diminishes Survival in CD72 Down-Modulates BCR-Induced Signal

Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells.

The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into the functions of Ebf1 at distinct stages of differentiation, we conditionally inactivated Ebf1. We found that Ebf1 is required for the proliferation, survival, and signaling of pro-B cells and peripheral B-cell subsets, including B1 cells and marginal zone B cells. The proliferation defect o...

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How this functional transition takes place is still controversial. In this study, we demonstrate that ablation of Foxo1 after GC development led to the loss of the DZ GC B cells and disruption of the GC architecture, wh...

Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

cells suggested that rather than marking a developmental checkpoint, the dependence of B cell maintenance on BCR expression is a characteristic feature of Summary B cell physiology from the stage of immature B cell generation in fetal liver or bone marrow (BM) to that of We previously showed that type I interferon-induced, Cre-mediated ablation of surface BCR expression in the mature, long-live...